Drug interactions
Enoxaparin + Parecoxib
Severity: Moderate
Enoxaparin and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to valdecoxib, a selective COX-2 inhibitor with little effect on platelet aggregation. Bleeding risk with enoxaparin is lower than with nonselective NSAIDs but GI bleeding risk remains and renal effects may matter.
What this interaction means in plain words
Enoxaparin and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive bleeding tendency through COX-2 related mucosal injury and enoxaparin anticoagulation; limited platelet effect.
What to do
Monitor for bleeding and renal function, particularly in elderly or renally impaired patients, as enoxaparin accumulates. Use the lowest effective parecoxib dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Enoxaparin with Parecoxib?
MediHelp rates the interaction as moderate. Enoxaparin and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib is converted to valdecoxib, a selective COX-2 inhibitor with little effect on platelet aggregation. Bleeding risk with enoxaparin is lower than with nonselective NSAIDs but GI bleeding risk remains and renal effects may matter.
How serious is the interaction between Enoxaparin and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function, particularly in elderly or renally impaired patients, as enoxaparin accumulates. Use the lowest effective parecoxib dose for the shortest time.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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