Drug interactions
Enoxaparin + Sacubitril / valsartan
Severity: Moderate
Enoxaparin and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins can suppress aldosterone secretion, and valsartan blocks angiotensin II effects on aldosterone, so together they can raise serum potassium. The risk is greater with renal impairment, diabetes or prolonged heparin use.
What this interaction means in plain words
Enoxaparin and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive suppression of aldosterone-mediated potassium excretion, resulting in hyperkalemia.
What to do
Monitor serum potassium and renal function, especially in high-risk patients or with prolonged therapy. Treat hyperkalemia and reconsider therapy if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Enoxaparin with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Enoxaparin and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins can suppress aldosterone secretion, and valsartan blocks angiotensin II effects on aldosterone, so together they can raise serum potassium. The risk is greater with renal impairment, diabetes or prolonged heparin use.
How serious is the interaction between Enoxaparin and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, especially in high-risk patients or with prolonged therapy. Treat hyperkalemia and reconsider therapy if levels rise.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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