Drug interactions
Enoxaparin + Salicylates
Severity: Moderate
Enoxaparin and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-aspirin salicylates may impair platelet function and irritate the gastric mucosa, which can add to the bleeding risk of enoxaparin. The magnitude varies by agent, with non-acetylated salicylates generally having weaker platelet effects than aspirin.
What this interaction means in plain words
Enoxaparin and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of hemostasis: salicylate effects on platelets and gastric mucosa combined with enoxaparin's anticoagulant effect.
What to do
Avoid unnecessary co-use and consider acetaminophen for analgesia. If combined, monitor for bleeding signs and hemoglobin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Enoxaparin with Salicylates?
MediHelp rates the interaction as moderate. Enoxaparin and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-aspirin salicylates may impair platelet function and irritate the gastric mucosa, which can add to the bleeding risk of enoxaparin. The magnitude varies by agent, with non-acetylated salicylates generally having weaker platelet effects than aspirin.
How serious is the interaction between Enoxaparin and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary co-use and consider acetaminophen for analgesia. If combined, monitor for bleeding signs and hemoglobin.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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