Drug interactions
Enoximone + Milrinone
Severity: Major
Enoximone and Milrinone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are phosphodiesterase-3 inhibitors with inotropic and vasodilating actions. Combining them duplicates therapy and increases the risk of hypotension and ventricular arrhythmias without a clear benefit.
What this interaction means in plain words
Enoximone and Milrinone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate PDE-3 inhibition causing additive increases in cAMP, inotropy and vasodilation.
What to do
Avoid concurrent use of two PDE-3 inhibitors; choose a single agent. If switching, stop the first drug and allow for its effect to wane before starting the other, with blood pressure and ECG monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Milrinone
- Anagrelide + Milrinone Major
- Cilostazol + Milrinone Major
- Inamrinone + Milrinone Major
- Milrinone + Olprinone Major
- Milrinone + Riociguat Major
- Milrinone + Ozanimod Minor
Frequently asked questions
Can I take Enoximone with Milrinone?
MediHelp rates the interaction as major. Enoximone and Milrinone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are phosphodiesterase-3 inhibitors with inotropic and vasodilating actions. Combining them duplicates therapy and increases the risk of hypotension and ventricular arrhythmias without a clear benefit.
How serious is the interaction between Enoximone and Milrinone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two PDE-3 inhibitors; choose a single agent. If switching, stop the first drug and allow for its effect to wane before starting the other, with blood pressure and ECG monitoring.
What other medicines interact with Milrinone?
MediHelp also lists interactions of Milrinone with, for example, Anagrelide, Cilostazol, Inamrinone. The full list is on the Milrinone page.
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