Drug interactions
Inamrinone + Milrinone
Severity: Major
Inamrinone and Milrinone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are phosphodiesterase-3 inhibitors with inotropic and vasodilating actions. Using them together duplicates therapy and increases the risk of hypotension, arrhythmias and, with inamrinone, thrombocytopenia.
What this interaction means in plain words
Inamrinone and Milrinone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate PDE-3 inhibition causing additive increases in cAMP, inotropy and vasodilation.
What to do
Avoid combining the two; use a single PDE-3 inhibitor. If switching, stop the first drug before starting the other and monitor blood pressure and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Milrinone
- Anagrelide + Milrinone Major
- Cilostazol + Milrinone Major
- Enoximone + Milrinone Major
- Milrinone + Olprinone Major
- Milrinone + Riociguat Major
- Milrinone + Ozanimod Minor
Frequently asked questions
Can I take Inamrinone with Milrinone?
MediHelp rates the interaction as major. Inamrinone and Milrinone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are phosphodiesterase-3 inhibitors with inotropic and vasodilating actions. Using them together duplicates therapy and increases the risk of hypotension, arrhythmias and, with inamrinone, thrombocytopenia.
How serious is the interaction between Inamrinone and Milrinone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two; use a single PDE-3 inhibitor. If switching, stop the first drug before starting the other and monitor blood pressure and ECG.
What other medicines interact with Milrinone?
MediHelp also lists interactions of Milrinone with, for example, Anagrelide, Cilostazol, Enoximone. The full list is on the Milrinone page.
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