Drug interactions
Entrectinib + Escitalopram
Severity: Major
Entrectinib and Escitalopram: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both entrectinib and escitalopram can prolong the QT interval, so together they may raise the risk of torsades de pointes. Entrectinib labeling advises caution with other QT-prolonging drugs.
What this interaction means in plain words
Entrectinib and Escitalopram can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Escitalopram belongs to Central Nervous System.
Why it happens
Additive QTc prolongation via cardiac repolarization effects.
What to do
Prefer a non-QT-prolonging antidepressant; if combined, monitor ECG and electrolytes and follow entrectinib dose-reduction guidance for QTc prolongation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Escitalopram?
MediHelp rates the interaction as major. Entrectinib and Escitalopram can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both entrectinib and escitalopram can prolong the QT interval, so together they may raise the risk of torsades de pointes. Entrectinib labeling advises caution with other QT-prolonging drugs.
How serious is the interaction between Entrectinib and Escitalopram?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-QT-prolonging antidepressant; if combined, monitor ECG and electrolytes and follow entrectinib dose-reduction guidance for QTc prolongation.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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