Drug interactions
Entrectinib + Isoniazid
Severity: Moderate
Entrectinib and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may inhibit CYP3A4 and increase entrectinib exposure, which could worsen QT prolongation, heart failure, CNS effects and hepatotoxicity.
What this interaction means in plain words
Entrectinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid inhibits CYP3A4, reducing entrectinib clearance, with additive hepatotoxicity.
What to do
Monitor ECG, liver tests and CNS symptoms, and reduce the entrectinib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Isoniazid?
MediHelp rates the interaction as moderate. Entrectinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid may inhibit CYP3A4 and increase entrectinib exposure, which could worsen QT prolongation, heart failure, CNS effects and hepatotoxicity.
How serious is the interaction between Entrectinib and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, liver tests and CNS symptoms, and reduce the entrectinib dose if toxicity occurs.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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