Drug interactions
Entrectinib + Levosalbutamol
Severity: Moderate
Entrectinib and Levosalbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and levosalbutamol may add to this risk via tachycardia and lowered serum potassium. The combination raises the possibility of torsades de pointes, especially with other risk factors.
What this interaction means in plain words
Entrectinib and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Levosalbutamol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization, with beta-2 agonist induced hypokalemia as a contributing factor.
What to do
Obtain a baseline ECG and correct potassium and magnesium disturbances. Monitor ECG and electrolytes during combined therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Levosalbutamol?
MediHelp rates the interaction as moderate. Entrectinib and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval, and levosalbutamol may add to this risk via tachycardia and lowered serum potassium. The combination raises the possibility of torsades de pointes, especially with other risk factors.
How serious is the interaction between Entrectinib and Levosalbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium disturbances. Monitor ECG and electrolytes during combined therapy.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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