Drug interactions
Entrectinib + Lithium
Severity: Moderate
Entrectinib and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and lithium may add to this effect. Together they may raise the risk of torsades de pointes, especially with electrolyte disturbance or bradycardia.
What this interaction means in plain words
Entrectinib and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Lithium belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor the ECG and electrolytes at baseline and during therapy. Consider an alternative or a dose reduction of entrectinib if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Lithium?
MediHelp rates the interaction as moderate. Entrectinib and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval, and lithium may add to this effect. Together they may raise the risk of torsades de pointes, especially with electrolyte disturbance or bradycardia.
How serious is the interaction between Entrectinib and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and electrolytes at baseline and during therapy. Consider an alternative or a dose reduction of entrectinib if the QTc becomes markedly prolonged.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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