Drug interactions
Entrectinib + Metronidazole
Severity: Moderate
Entrectinib and Metronidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib is a CYP3A4 substrate and QT-prolonging agent. Metronidazole is not an established CYP3A4 inhibitor, but it has been associated with QT prolongation, so additive effects are theoretically possible.
What this interaction means in plain words
Entrectinib and Metronidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Metronidazole belongs to Anti Parasitic.
Why it happens
Possible weak CYP3A4 inhibition and additive QT prolongation.
What to do
Monitor ECG and electrolytes during coadministration, and correct potassium and magnesium. Consider an alternative antibiotic if QT prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Metronidazole?
MediHelp rates the interaction as moderate. Entrectinib and Metronidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib is a CYP3A4 substrate and QT-prolonging agent. Metronidazole is not an established CYP3A4 inhibitor, but it has been associated with QT prolongation, so additive effects are theoretically possible.
How serious is the interaction between Entrectinib and Metronidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes during coadministration, and correct potassium and magnesium. Consider an alternative antibiotic if QT prolongation develops.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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