Drug interactions
Entrectinib + Olanzapine
Severity: Moderate
Entrectinib and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib is associated with QT prolongation, and olanzapine may add a small effect. Combined use may raise arrhythmia risk, especially with electrolyte disorders or cardiac disease.
What this interaction means in plain words
Entrectinib and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Olanzapine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization.
What to do
Monitor ECG and electrolytes, and correct hypokalemia and hypomagnesemia. Reduce or withhold entrectinib if QTc prolongation becomes significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Olanzapine?
MediHelp rates the interaction as moderate. Entrectinib and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib is associated with QT prolongation, and olanzapine may add a small effect. Combined use may raise arrhythmia risk, especially with electrolyte disorders or cardiac disease.
How serious is the interaction between Entrectinib and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and correct hypokalemia and hypomagnesemia. Reduce or withhold entrectinib if QTc prolongation becomes significant.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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