Drug interactions
Entrectinib + Venlafaxine
Severity: Moderate
Entrectinib and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval and venlafaxine may add to this effect. The combination increases the potential for ventricular arrhythmia, especially with electrolyte disturbances.
What this interaction means in plain words
Entrectinib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Venlafaxine belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation.
What to do
Monitor ECG and electrolytes and avoid other QT-prolonging drugs where possible. Interrupt or reduce entrectinib per labeling if significant QTc prolongation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Venlafaxine?
MediHelp rates the interaction as moderate. Entrectinib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval and venlafaxine may add to this effect. The combination increases the potential for ventricular arrhythmia, especially with electrolyte disturbances.
How serious is the interaction between Entrectinib and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes and avoid other QT-prolonging drugs where possible. Interrupt or reduce entrectinib per labeling if significant QTc prolongation occurs.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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