Drug interactions
Epinephrine + Foscarnet
Severity: Moderate
Epinephrine and Foscarnet: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine can provoke arrhythmias and, especially with hypokalemia or hypomagnesemia, may contribute to QT-related risk. Foscarnet adds electrolyte disturbance and some QT prolongation. The concern is mainly for non-emergency, repeated or high-dose epinephrine use.
What this interaction means in plain words
Epinephrine and Foscarnet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Foscarnet belongs to Anti Virals.
Why it happens
Additive proarrhythmic effects through adrenergic stimulation and foscarnet-related QT prolongation and electrolyte shifts.
What to do
Do not withhold epinephrine in emergencies; otherwise monitor ECG and correct electrolytes during co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Foscarnet?
MediHelp rates the interaction as moderate. Epinephrine and Foscarnet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine can provoke arrhythmias and, especially with hypokalemia or hypomagnesemia, may contribute to QT-related risk. Foscarnet adds electrolyte disturbance and some QT prolongation. The concern is mainly for non-emergency, repeated or high-dose epinephrine use.
How serious is the interaction between Epinephrine and Foscarnet?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not withhold epinephrine in emergencies; otherwise monitor ECG and correct electrolytes during co-therapy.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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