Drug interactions
Epinephrine + Hydralazine
Severity: Moderate
Epinephrine and Hydralazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine raises heart rate, cardiac output and blood pressure, which can counteract the blood pressure lowering of hydralazine. Hydralazine-induced reflex tachycardia may also be exaggerated.
What this interaction means in plain words
Epinephrine and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Hydralazine belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism between adrenergic vasopressor and cardiac stimulation and arterial vasodilation.
What to do
Monitor blood pressure and heart rate when both are given. Titrate hydralazine or epinephrine to the hemodynamic target.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Hydralazine?
MediHelp rates the interaction as moderate. Epinephrine and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine raises heart rate, cardiac output and blood pressure, which can counteract the blood pressure lowering of hydralazine. Hydralazine-induced reflex tachycardia may also be exaggerated.
How serious is the interaction between Epinephrine and Hydralazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when both are given. Titrate hydralazine or epinephrine to the hemodynamic target.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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