Drug interactions
Epinephrine + Insulin degludec-liraglutide
Severity: Moderate
Epinephrine and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine raises blood glucose and can offset the glucose-lowering action of insulin degludec and liraglutide. Glycemic control may deteriorate, particularly with repeated or prolonged epinephrine exposure.
What this interaction means in plain words
Epinephrine and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Beta- and alpha-adrenergic stimulation increases hepatic glucose output and glycogenolysis and suppresses insulin secretion, opposing antidiabetic effects.
What to do
Monitor blood glucose more frequently when epinephrine is given beyond emergency single doses. Adjust the insulin dose if hyperglycemia persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Epinephrine and Insulin degludec-liraglutide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin degludec-liraglutide
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Epinephrine and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine raises blood glucose and can offset the glucose-lowering action of insulin degludec and liraglutide. Glycemic control may deteriorate, particularly with repeated or prolonged epinephrine exposure.
How serious is the interaction between Epinephrine and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when epinephrine is given beyond emergency single doses. Adjust the insulin dose if hyperglycemia persists.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
