Drug interactions
Epinephrine + Lorazepam
Severity: Minor
Epinephrine and Lorazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine is a sympathomimetic with CNS stimulating effects that can partly oppose sedation from lorazepam. No meaningful interaction of clinical significance is expected in typical use, such as emergency or local anesthetic use.
What this interaction means in plain words
Epinephrine and Lorazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Epinephrine belongs to Endocrine; Lorazepam belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects; no established pharmacokinetic interaction.
What to do
No specific action is needed. Treat each drug according to the clinical indication and monitor the patient's response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lorazepam
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Lorazepam?
MediHelp rates the interaction as minor. Epinephrine and Lorazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Epinephrine is a sympathomimetic with CNS stimulating effects that can partly oppose sedation from lorazepam. No meaningful interaction of clinical significance is expected in typical use, such as emergency or local anesthetic use.
How serious is the interaction between Epinephrine and Lorazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed. Treat each drug according to the clinical indication and monitor the patient's response.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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