Drug interactions
Epinephrine + Nateglinide
Severity: Moderate
Epinephrine and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine raises blood glucose by promoting glycogenolysis and gluconeogenesis and by suppressing insulin secretion. This opposes the glucose-lowering effect of nateglinide and may worsen glycemic control, especially with repeated or systemic doses.
What this interaction means in plain words
Epinephrine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: adrenergic hyperglycemic effects oppose insulin secretagogue action.
What to do
Monitor blood glucose when systemic epinephrine is used repeatedly or for prolonged periods, and adjust antidiabetic therapy as needed. Single emergency doses generally need no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Nateglinide?
MediHelp rates the interaction as moderate. Epinephrine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine raises blood glucose by promoting glycogenolysis and gluconeogenesis and by suppressing insulin secretion. This opposes the glucose-lowering effect of nateglinide and may worsen glycemic control, especially with repeated or systemic doses.
How serious is the interaction between Epinephrine and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when systemic epinephrine is used repeatedly or for prolonged periods, and adjust antidiabetic therapy as needed. Single emergency doses generally need no change.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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