Drug interactions
Epinephrine + Pseudoephedrine
Severity: Moderate
Epinephrine and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined use produces additive sympathomimetic effects, including hypertension, tachycardia and arrhythmias. This matters especially in patients with coronary disease or when epinephrine is given systemically.
What this interaction means in plain words
Epinephrine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Pseudoephedrine belongs to Respiratory.
Why it happens
Additive adrenergic receptor stimulation.
What to do
Monitor blood pressure, heart rate and ECG when systemic epinephrine is given to patients taking pseudoephedrine. Do not withhold epinephrine in anaphylaxis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Pseudoephedrine?
MediHelp rates the interaction as moderate. Epinephrine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined use produces additive sympathomimetic effects, including hypertension, tachycardia and arrhythmias. This matters especially in patients with coronary disease or when epinephrine is given systemically.
How serious is the interaction between Epinephrine and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG when systemic epinephrine is given to patients taking pseudoephedrine. Do not withhold epinephrine in anaphylaxis.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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