Drug interactions
Epinephrine + Rasagiline
Severity: Moderate
Epinephrine and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine is cleared in part by MAO and COMT, and MAO inhibition may potentiate its cardiovascular effects. Hypertension and tachycardia are possible, though selective MAO-B inhibition at usual doses carries less risk than nonselective inhibition.
What this interaction means in plain words
Epinephrine and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Rasagiline belongs to Central Nervous System.
Why it happens
Additive sympathomimetic effects with reduced catecholamine breakdown through MAO inhibition.
What to do
Monitor blood pressure and heart rate when epinephrine is given, and use the lowest effective dose. Do not withhold epinephrine in anaphylaxis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Rasagiline?
MediHelp rates the interaction as moderate. Epinephrine and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine is cleared in part by MAO and COMT, and MAO inhibition may potentiate its cardiovascular effects. Hypertension and tachycardia are possible, though selective MAO-B inhibition at usual doses carries less risk than nonselective inhibition.
How serious is the interaction between Epinephrine and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when epinephrine is given, and use the lowest effective dose. Do not withhold epinephrine in anaphylaxis.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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