Drug interactions
Epinephrine + Sacubitril-valsartan
Severity: Minor
Epinephrine and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine lowers serum potassium via beta-2 stimulation, opposing the potassium-retaining effect of the angiotensin receptor blocker. It also raises blood pressure and heart rate, which may counter the antihypertensive effect, though hypotension may still occur in shock states.
What this interaction means in plain words
Epinephrine and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Epinephrine belongs to Endocrine; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Beta-2-mediated cellular potassium uptake and opposing hemodynamic effects.
What to do
Monitor serum potassium and blood pressure when epinephrine is given repeatedly or by infusion. No action is needed for single emergency doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Epinephrine and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Epinephrine lowers serum potassium via beta-2 stimulation, opposing the potassium-retaining effect of the angiotensin receptor blocker. It also raises blood pressure and heart rate, which may counter the antihypertensive effect, though hypotension may still occur in shock states.
How serious is the interaction between Epinephrine and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure when epinephrine is given repeatedly or by infusion. No action is needed for single emergency doses.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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