Drug interactions
Epinephrine inhaled + Imipramine
Severity: Moderate
Epinephrine inhaled and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of sympathomimetics such as epinephrine by blocking neuronal reuptake of catecholamines. This may cause raised blood pressure, tachycardia and arrhythmias. Inhaled doses are small, so the effect is usually modest, but sensitive patients can be affected.
What this interaction means in plain words
Epinephrine inhaled and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclic inhibition of norepinephrine reuptake enhances adrenergic responses to epinephrine.
What to do
Monitor heart rate, blood pressure and rhythm, and use the lowest effective epinephrine dose. Be especially careful in patients with cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Epinephrine inhaled with Imipramine?
MediHelp rates the interaction as moderate. Epinephrine inhaled and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of sympathomimetics such as epinephrine by blocking neuronal reuptake of catecholamines. This may cause raised blood pressure, tachycardia and arrhythmias. Inhaled doses are small, so the effect is usually modest, but sensitive patients can be affected.
How serious is the interaction between Epinephrine inhaled and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and rhythm, and use the lowest effective epinephrine dose. Be especially careful in patients with cardiovascular disease.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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