Drug interactions
Epinephrine inhaled + Isocarboxazid
Severity: Contraindicated
Epinephrine inhaled and Isocarboxazid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAOIs can intensify the cardiovascular effects of epinephrine, causing hypertension, tachycardia and arrhythmias. Labeling prohibits use during and within two weeks of MAOI therapy.
What this interaction means in plain words
Epinephrine inhaled and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition reduces catecholamine metabolism and enhances adrenergic responses, additive to epinephrine.
What to do
Avoid inhaled epinephrine and use an alternative bronchodilator. Seek medical advice before using it for emergency purposes if on an MAOI.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Epinephrine inhaled with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Epinephrine inhaled and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAOIs can intensify the cardiovascular effects of epinephrine, causing hypertension, tachycardia and arrhythmias. Labeling prohibits use during and within two weeks of MAOI therapy.
How serious is the interaction between Epinephrine inhaled and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid inhaled epinephrine and use an alternative bronchodilator. Seek medical advice before using it for emergency purposes if on an MAOI.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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