Drug interactions
Epinephrine inhaled + Pseudoephedrine
Severity: Moderate
Epinephrine inhaled and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled epinephrine has some systemic absorption and can add to the pressor and chronotropic effects of pseudoephedrine. This may cause palpitations, tachycardia, tremor and increased blood pressure.
What this interaction means in plain words
Epinephrine inhaled and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic stimulation from direct alpha/beta agonism and indirect sympathomimetic action.
What to do
Monitor heart rate and blood pressure and advise patients to report palpitations or chest pain. Avoid pseudoephedrine in patients with significant cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Epinephrine inhaled with Pseudoephedrine?
MediHelp rates the interaction as moderate. Epinephrine inhaled and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled epinephrine has some systemic absorption and can add to the pressor and chronotropic effects of pseudoephedrine. This may cause palpitations, tachycardia, tremor and increased blood pressure.
How serious is the interaction between Epinephrine inhaled and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and advise patients to report palpitations or chest pain. Avoid pseudoephedrine in patients with significant cardiovascular disease.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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