Drug interactions
Epinephrine racemic + Eprosartan-hydrochlorothiazide
Severity: Moderate
Epinephrine racemic and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine stimulates beta-2 receptors and shifts potassium into cells, and hydrochlorothiazide causes renal potassium loss. Together they can lower serum potassium more than either alone, which may promote arrhythmias, particularly with systemic or high-dose use.
What this interaction means in plain words
Epinephrine racemic and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2-mediated intracellular potassium shift plus thiazide-induced renal potassium wasting.
What to do
Monitor serum potassium and ECG in patients at risk when systemic or frequent epinephrine is used. Replace potassium or adjust the diuretic if hypokalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Epinephrine racemic with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Epinephrine racemic and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine stimulates beta-2 receptors and shifts potassium into cells, and hydrochlorothiazide causes renal potassium loss. Together they can lower serum potassium more than either alone, which may promote arrhythmias, particularly with systemic or high-dose use.
How serious is the interaction between Epinephrine racemic and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG in patients at risk when systemic or frequent epinephrine is used. Replace potassium or adjust the diuretic if hypokalemia develops.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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