Drug interactions
Epinephrine racemic + Hydrochlorothiazide-valsartan
Severity: Moderate
Epinephrine racemic and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine can lower serum potassium through beta-2 stimulation, and with hydrochlorothiazide this may cause additive hypokalemia. Systemic epinephrine may also raise blood pressure and oppose antihypertensive therapy.
What this interaction means in plain words
Epinephrine racemic and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 mediated cellular potassium uptake adds to thiazide renal potassium loss.
What to do
Monitor serum potassium and blood pressure when systemic or repeated doses are used, and replace potassium if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Epinephrine racemic with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Epinephrine racemic and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine can lower serum potassium through beta-2 stimulation, and with hydrochlorothiazide this may cause additive hypokalemia. Systemic epinephrine may also raise blood pressure and oppose antihypertensive therapy.
How serious is the interaction between Epinephrine racemic and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure when systemic or repeated doses are used, and replace potassium if low.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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