Drug interactions
Epinephrine racemic + Isocarboxazid
Severity: Contraindicated
Epinephrine racemic and Isocarboxazid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine is a direct sympathomimetic whose effects are intensified in patients on MAO inhibitors. Severe hypertension, headache and arrhythmias can follow, even with inhaled or topical use.
What this interaction means in plain words
Epinephrine racemic and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition increases availability of catecholamines and sensitizes adrenergic receptors, giving additive pressor and cardiac effects.
What to do
Avoid use during isocarboxazid therapy and for 14 days after stopping it. Use non-adrenergic alternatives for airway symptoms.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Epinephrine racemic with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Epinephrine racemic and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Racemic epinephrine is a direct sympathomimetic whose effects are intensified in patients on MAO inhibitors. Severe hypertension, headache and arrhythmias can follow, even with inhaled or topical use.
How serious is the interaction between Epinephrine racemic and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use during isocarboxazid therapy and for 14 days after stopping it. Use non-adrenergic alternatives for airway symptoms.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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