Drug interactions
Epinephrine racemic + Ketoconazole
Severity: Minor
Epinephrine racemic and Ketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine is a sympathomimetic that can provoke arrhythmias, and ketoconazole can prolong QT. Clinical significance is likely limited with inhaled use, as systemic exposure is small.
What this interaction means in plain words
Epinephrine racemic and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive proarrhythmic effects; no meaningful pharmacokinetic interaction is established.
What to do
No routine change is needed; monitor heart rhythm in patients with QT risk factors or when high or systemic doses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Epinephrine racemic with Ketoconazole?
MediHelp rates the interaction as minor. Epinephrine racemic and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Racemic epinephrine is a sympathomimetic that can provoke arrhythmias, and ketoconazole can prolong QT. Clinical significance is likely limited with inhaled use, as systemic exposure is small.
How serious is the interaction between Epinephrine racemic and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor heart rhythm in patients with QT risk factors or when high or systemic doses are used.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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