Drug interactions
Epinephrine racemic + Paroxetine
Severity: Minor
Epinephrine racemic and Paroxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine, used mainly by inhalation, has little systemic exposure at usual doses, and the QT-based concern is theoretical. Systemic sympathomimetic effects could in principle add to the small QT effect of paroxetine, and SSRIs may modestly heighten pressor responses.
What this interaction means in plain words
Epinephrine racemic and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive effects on cardiac repolarization and adrenergic response; not firmly established.
What to do
No routine change is needed with inhaled use. Monitor heart rate, blood pressure and rhythm if larger or repeated doses are given in patients with heart disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Epinephrine racemic with Paroxetine?
MediHelp rates the interaction as minor. Epinephrine racemic and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Racemic epinephrine, used mainly by inhalation, has little systemic exposure at usual doses, and the QT-based concern is theoretical. Systemic sympathomimetic effects could in principle add to the small QT effect of paroxetine, and SSRIs may modestly heighten pressor responses.
How serious is the interaction between Epinephrine racemic and Paroxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed with inhaled use. Monitor heart rate, blood pressure and rhythm if larger or repeated doses are given in patients with heart disease.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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