Drug interactions
Epinephrine racemic + Pseudoephedrine
Severity: Moderate
Epinephrine racemic and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine, usually nebulized, can add to the cardiovascular stimulation from pseudoephedrine, causing tachycardia, palpitations and raised blood pressure. The effect is more important in patients with heart disease or hypertension.
What this interaction means in plain words
Epinephrine racemic and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic effects from direct alpha/beta agonism and indirect norepinephrine release.
What to do
Monitor heart rate and blood pressure during and after treatment. Avoid pseudoephedrine in patients with significant cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Epinephrine racemic with Pseudoephedrine?
MediHelp rates the interaction as moderate. Epinephrine racemic and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Racemic epinephrine, usually nebulized, can add to the cardiovascular stimulation from pseudoephedrine, causing tachycardia, palpitations and raised blood pressure. The effect is more important in patients with heart disease or hypertension.
How serious is the interaction between Epinephrine racemic and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure during and after treatment. Avoid pseudoephedrine in patients with significant cardiac disease.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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