Drug interactions
Epinephrine racemic + Sacubitril-valsartan
Severity: Minor
Epinephrine racemic and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan tends to raise serum potassium, while epinephrine stimulates beta-2 receptors and can lower it by driving potassium into cells. The net potassium effect is uncertain and generally of limited clinical significance with inhaled or occasional use.
What this interaction means in plain words
Epinephrine racemic and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing effects on serum potassium from angiotensin receptor blockade and beta-2 adrenergic stimulation.
What to do
No routine action is required; check potassium if racemic epinephrine is used frequently or systemically in a patient on sacubitril-valsartan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Epinephrine racemic with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Epinephrine racemic and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan tends to raise serum potassium, while epinephrine stimulates beta-2 receptors and can lower it by driving potassium into cells. The net potassium effect is uncertain and generally of limited clinical significance with inhaled or occasional use.
How serious is the interaction between Epinephrine racemic and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is required; check potassium if racemic epinephrine is used frequently or systemically in a patient on sacubitril-valsartan.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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