Drug interactions
Epinephrine racemic + Salbutamol
Severity: Moderate
Epinephrine racemic and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine and salbutamol are both adrenergic agonists, so combined use gives additive cardiovascular stimulation. Tachycardia, arrhythmias, hypertension and hypokalemia may occur.
What this interaction means in plain words
Epinephrine racemic and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic receptor agonism, including beta-2 mediated potassium shift.
What to do
Avoid giving them together or in close succession unless needed, and monitor ECG, blood pressure and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Frequently asked questions
Can I take Epinephrine racemic with Salbutamol?
MediHelp rates the interaction as moderate. Epinephrine racemic and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Racemic epinephrine and salbutamol are both adrenergic agonists, so combined use gives additive cardiovascular stimulation. Tachycardia, arrhythmias, hypertension and hypokalemia may occur.
How serious is the interaction between Epinephrine racemic and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving them together or in close succession unless needed, and monitor ECG, blood pressure and potassium.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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