Drug interactions
Epoprostenol + Ginko biloba
Severity: Moderate
Epoprostenol and Ginko biloba: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent inhibitor of platelet aggregation, and ginkgo may add a mild antiplatelet effect. Bleeding risk may therefore be somewhat higher.
What this interaction means in plain words
Epoprostenol and Ginko biloba can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epoprostenol belongs to Genitourinary; Ginko biloba belongs to Gastrointestinal Tract.
Why it happens
Additive antiplatelet effect: prostacyclin-mediated inhibition of aggregation plus ginkgo's PAF antagonism.
What to do
Avoid ginkgo in patients on epoprostenol where possible, and monitor for bleeding if it is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ginko biloba
- Ginko biloba + Ketorolac Major
- Abciximab + Ginko biloba Moderate
- Aceclofenac + Ginko biloba Moderate
- Acemetacin + Ginko biloba Moderate
- Alteplase + Ginko biloba Moderate
- Anagrelide + Ginko biloba Moderate
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Ginko biloba?
MediHelp rates the interaction as moderate. Epoprostenol and Ginko biloba can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol is a potent inhibitor of platelet aggregation, and ginkgo may add a mild antiplatelet effect. Bleeding risk may therefore be somewhat higher.
How serious is the interaction between Epoprostenol and Ginko biloba?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ginkgo in patients on epoprostenol where possible, and monitor for bleeding if it is used.
What other medicines interact with Ginko biloba?
MediHelp also lists interactions of Ginko biloba with, for example, Ketorolac, Abciximab, Aceclofenac. The full list is on the Ginko biloba page.
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