Drug interactions
Epoprostenol + Hydrochlorothiazide-olmesartan
Severity: Moderate
Epoprostenol and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent vasodilator and can lower blood pressure. Combined with olmesartan and hydrochlorothiazide, hypotension may be more pronounced, particularly during dose titration.
What this interaction means in plain words
Epoprostenol and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epoprostenol belongs to Genitourinary; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic vasodilation and blood pressure lowering, plus diuretic volume depletion.
What to do
Monitor blood pressure and symptoms of hypotension when starting or titrating epoprostenol, and reduce antihypertensive doses if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Epoprostenol and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol is a potent vasodilator and can lower blood pressure. Combined with olmesartan and hydrochlorothiazide, hypotension may be more pronounced, particularly during dose titration.
How serious is the interaction between Epoprostenol and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or titrating epoprostenol, and reduce antihypertensive doses if hypotension develops.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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