Drug interactions
Epoprostenol + Indapamide
Severity: Minor
Epoprostenol and Indapamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent vasodilator, and combining it with a diuretic such as indapamide may cause additive blood pressure lowering. Volume depletion from the diuretic may worsen hypotension.
What this interaction means in plain words
Epoprostenol and Indapamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Epoprostenol belongs to Genitourinary; Indapamide belongs to Cardiovascular.
Why it happens
Additive hypotensive effect from vasodilation and diuresis.
What to do
Monitor blood pressure and volume status when starting or adjusting either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indapamide
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Indapamide?
MediHelp rates the interaction as minor. Epoprostenol and Indapamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Epoprostenol is a potent vasodilator, and combining it with a diuretic such as indapamide may cause additive blood pressure lowering. Volume depletion from the diuretic may worsen hypotension.
How serious is the interaction between Epoprostenol and Indapamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and volume status when starting or adjusting either drug.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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