Drug interactions
Eprosartan + Fenoprofen
Severity: Moderate
Eprosartan and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs blunt the blood pressure lowering effect of angiotensin receptor blockers and can precipitate acute kidney injury, especially in elderly or volume-depleted patients. Hyperkalemia may also occur.
What this interaction means in plain words
Eprosartan and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan belongs to Cardiovascular; Fenoprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal vasodilatory prostaglandins reduces glomerular perfusion while angiotensin II blockade removes efferent arteriolar tone, impairing filtration and sodium excretion.
What to do
Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting the NSAID. Use the shortest NSAID course or choose an alternative analgesic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Fenoprofen?
MediHelp rates the interaction as moderate. Eprosartan and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs blunt the blood pressure lowering effect of angiotensin receptor blockers and can precipitate acute kidney injury, especially in elderly or volume-depleted patients. Hyperkalemia may also occur.
How serious is the interaction between Eprosartan and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting the NSAID. Use the shortest NSAID course or choose an alternative analgesic where possible.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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