Drug interactions
Eprosartan + Indapamide
Severity: Moderate
Eprosartan and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination gives additive blood pressure lowering, and hypotension or reduced renal function may occur in volume-depleted patients. Eprosartan tends to raise potassium and indapamide tends to lower it, so the net effect varies.
What this interaction means in plain words
Eprosartan and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect, with opposing effects on potassium excretion from angiotensin receptor blockade and diuretic action.
What to do
Monitor blood pressure, serum potassium and creatinine after starting or changing doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eprosartan and Indapamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Indapamide
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Indapamide?
MediHelp rates the interaction as moderate. Eprosartan and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination gives additive blood pressure lowering, and hypotension or reduced renal function may occur in volume-depleted patients. Eprosartan tends to raise potassium and indapamide tends to lower it, so the net effect varies.
How serious is the interaction between Eprosartan and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and creatinine after starting or changing doses.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
