Drug interactions
Eprosartan + Insulin aspart protamine / insulin aspart
Severity: Moderate
Eprosartan and Insulin aspart protamine / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ARBs may improve insulin sensitivity and so enhance the glucose-lowering effect of insulin. This can increase the likelihood of hypoglycemia, particularly after starting the ARB. The effect is usually modest.
What this interaction means in plain words
Eprosartan and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose lowering, likely via improved insulin sensitivity with angiotensin receptor blockade.
What to do
Increase glucose monitoring when eprosartan is started or stopped. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Insulin aspart protamine / insulin aspart?
MediHelp rates the interaction as moderate. Eprosartan and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ARBs may improve insulin sensitivity and so enhance the glucose-lowering effect of insulin. This can increase the likelihood of hypoglycemia, particularly after starting the ARB. The effect is usually modest.
How serious is the interaction between Eprosartan and Insulin aspart protamine / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase glucose monitoring when eprosartan is started or stopped. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
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