Drug interactions
Eprosartan + Ketorolac intranasal
Severity: Major
Eprosartan and Ketorolac intranasal: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is an NSAID that can reduce the antihypertensive effect of ARBs and impair renal function, especially in elderly or volume-depleted patients. Hyperkalemia risk is also increased. Intranasal dosing still gives meaningful systemic exposure.
What this interaction means in plain words
Eprosartan and Ketorolac intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium and potassium handling, opposing ARB effects and adding to the risk of acute kidney injury.
What to do
Avoid combining where possible, and keep ketorolac to the shortest course. Monitor blood pressure, creatinine and potassium and maintain hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Ketorolac intranasal?
MediHelp rates the interaction as major. Eprosartan and Ketorolac intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketorolac is an NSAID that can reduce the antihypertensive effect of ARBs and impair renal function, especially in elderly or volume-depleted patients. Hyperkalemia risk is also increased. Intranasal dosing still gives meaningful systemic exposure.
How serious is the interaction between Eprosartan and Ketorolac intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, and keep ketorolac to the shortest course. Monitor blood pressure, creatinine and potassium and maintain hydration.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
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