Drug interactions
Eprosartan + Meclofenamate
Severity: Moderate
Eprosartan and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate, an NSAID, can weaken the blood pressure-lowering effect of eprosartan and raise the risk of renal impairment, particularly in elderly or volume-depleted patients. Hyperkalemia can also occur.
What this interaction means in plain words
Eprosartan and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of vasodilatory renal prostaglandins reduces renal perfusion and potassium excretion, opposing ARB effects.
What to do
Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eprosartan and Meclofenamate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Meclofenamate?
MediHelp rates the interaction as moderate. Eprosartan and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate, an NSAID, can weaken the blood pressure-lowering effect of eprosartan and raise the risk of renal impairment, particularly in elderly or volume-depleted patients. Hyperkalemia can also occur.
How serious is the interaction between Eprosartan and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
