Drug interactions
Eprosartan + Parecoxib
Severity: Moderate
Eprosartan and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to the COX-2 inhibitor valdecoxib and, like other NSAIDs, can reduce the antihypertensive effect of ARBs and impair renal function. Hyperkalemia may also occur, particularly in elderly or dehydrated patients.
What this interaction means in plain words
Eprosartan and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
COX-2 inhibition reduces renal prostaglandin synthesis, lowering renal perfusion and potassium excretion and opposing ARB effects.
What to do
Monitor blood pressure, creatinine and potassium, and ensure hydration. Limit parecoxib to the shortest effective duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Parecoxib?
MediHelp rates the interaction as moderate. Eprosartan and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib is converted to the COX-2 inhibitor valdecoxib and, like other NSAIDs, can reduce the antihypertensive effect of ARBs and impair renal function. Hyperkalemia may also occur, particularly in elderly or dehydrated patients.
How serious is the interaction between Eprosartan and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium, and ensure hydration. Limit parecoxib to the shortest effective duration.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
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