Drug interactions
Eprosartan + Sacubitril / valsartan
Severity: Major
Eprosartan and Sacubitril / valsartan: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eprosartan and valsartan (within sacubitril/valsartan) are both angiotensin II receptor blockers, so combining them gives duplicate blockade of the same system. This raises the risk of hyperkalemia, hypotension and renal impairment without a clear added benefit.
What this interaction means in plain words
Eprosartan and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate angiotensin II type 1 receptor blockade reduces aldosterone-mediated potassium excretion and lowers glomerular filtration pressure.
What to do
Avoid using two ARBs together and keep a single agent. If sacubitril/valsartan is started, stop eprosartan and monitor potassium, creatinine and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Eprosartan 300mg film-coated tablets - SmPC sections 4.3/4.5 (class statement: angiotensin II receptor blockers; "dual blockade of the reninangiotensinaldosteronesystem (RAAS) through the combined use of ACEinhibitors, angiotensin II receptor blockers or aliskiren") — electronic medicines compendium (UK SmPC)
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Sacubitril / valsartan?
MediHelp rates the interaction as major. Eprosartan and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eprosartan and valsartan (within sacubitril/valsartan) are both angiotensin II receptor blockers, so combining them gives duplicate blockade of the same system. This raises the risk of hyperkalemia, hypotension and renal impairment without a clear added benefit.
How serious is the interaction between Eprosartan and Sacubitril / valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two ARBs together and keep a single agent. If sacubitril/valsartan is started, stop eprosartan and monitor potassium, creatinine and blood pressure.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
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