Drug interactions
Eprosartan + Salicylates
Severity: Moderate
Eprosartan and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates have prostaglandin-inhibiting effects that can blunt the antihypertensive action of eprosartan. Together they can reduce renal function, especially in elderly or volume-depleted patients, and may raise potassium.
What this interaction means in plain words
Eprosartan and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandins reduces renal perfusion and opposes ARB effects, while ARB-related reduced aldosterone adds to potassium retention.
What to do
Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium when starting or changing the salicylate dose. Use the lowest effective dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Salicylates?
MediHelp rates the interaction as moderate. Eprosartan and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates have prostaglandin-inhibiting effects that can blunt the antihypertensive action of eprosartan. Together they can reduce renal function, especially in elderly or volume-depleted patients, and may raise potassium.
How serious is the interaction between Eprosartan and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium when starting or changing the salicylate dose. Use the lowest effective dose for the shortest time.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
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