Drug interactions
Eprosartan + Salsalate
Severity: Moderate
Eprosartan and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is an NSAID-type salicylate and can weaken the blood pressure lowering effect of eprosartan. The combination may also impair kidney function and raise potassium, particularly in older or dehydrated patients.
What this interaction means in plain words
Eprosartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin synthesis inhibition reduces renal blood flow and sodium excretion, counteracting ARB effects and adding to renal hemodynamic stress and potassium retention.
What to do
Monitor blood pressure, serum creatinine and potassium after starting salsalate and keep the patient well hydrated. Consider a non-NSAID analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Salsalate?
MediHelp rates the interaction as moderate. Eprosartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is an NSAID-type salicylate and can weaken the blood pressure lowering effect of eprosartan. The combination may also impair kidney function and raise potassium, particularly in older or dehydrated patients.
How serious is the interaction between Eprosartan and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting salsalate and keep the patient well hydrated. Consider a non-NSAID analgesic in high-risk patients.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
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