Drug interactions
Eprosartan + Synthetic human angiotensin ii
Severity: Moderate
Eprosartan and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eprosartan blocks the AT1 receptor through which angiotensin II exerts its pressor effect. Patients taking an ARB may therefore respond less to infused angiotensin II, so higher doses may be needed to raise blood pressure in vasodilatory shock.
What this interaction means in plain words
Eprosartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive antagonism of AT1 receptors by eprosartan opposes the vasoconstrictor action of exogenous angiotensin II.
What to do
Titrate angiotensin II to the blood pressure response and expect higher dose requirements in patients on ARBs. Monitor mean arterial pressure closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Eprosartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eprosartan blocks the AT1 receptor through which angiotensin II exerts its pressor effect. Patients taking an ARB may therefore respond less to infused angiotensin II, so higher doses may be needed to raise blood pressure in vasodilatory shock.
How serious is the interaction between Eprosartan and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate angiotensin II to the blood pressure response and expect higher dose requirements in patients on ARBs. Monitor mean arterial pressure closely.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
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