Drug interactions
Eprosartan-hydrochlorothiazide + Exenatide injectable
Severity: Moderate
Eprosartan-hydrochlorothiazide and Exenatide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can worsen glucose tolerance and may reduce the glucose-lowering effect of exenatide. Eprosartan may modestly improve insulin sensitivity, so net glycemic control can shift in either direction when these are started or stopped.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Exenatide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-induced impairment of insulin sensitivity and secretion opposes exenatide, while angiotensin receptor blockade may slightly improve insulin sensitivity.
What to do
Monitor blood glucose and HbA1c when starting, stopping or changing doses of the antihypertensive combination. Adjust antidiabetic therapy if control changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Exenatide injectable?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Exenatide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can worsen glucose tolerance and may reduce the glucose-lowering effect of exenatide. Eprosartan may modestly improve insulin sensitivity, so net glycemic control can shift in either direction when these are started or stopped.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Exenatide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when starting, stopping or changing doses of the antihypertensive combination. Adjust antidiabetic therapy if control changes.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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