Drug interactions
Eprosartan-hydrochlorothiazide + Fentanyl intranasal
Severity: Minor
Eprosartan-hydrochlorothiazide and Fentanyl intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl may reduce diuretic response through ADH release and can cause urinary retention. It may also contribute to hypotension when combined with antihypertensives and volume depletion.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Fentanyl intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced ADH release and urinary retention may antagonize diuretic effect; additive hypotension is possible.
What to do
Monitor blood pressure, fluid balance and urinary output; reassess diuretic dosing if edema or retention develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Fentanyl intranasal?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Fentanyl intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fentanyl may reduce diuretic response through ADH release and can cause urinary retention. It may also contribute to hypotension when combined with antihypertensives and volume depletion.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Fentanyl intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid balance and urinary output; reassess diuretic dosing if edema or retention develops.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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