Drug interactions
Eprosartan-hydrochlorothiazide + Fentanyl
Severity: Minor
Eprosartan-hydrochlorothiazide and Fentanyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can enhance antidiuretic hormone release and cause urinary retention, which may reduce diuretic effect. Fentanyl may also add to hypotension with antihypertensives. The effect is generally small and variable.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Fentanyl belongs to Musculoskeletal.
Why it happens
Opioid-related antidiuretic hormone release and additive hypotensive effects; the diuretic antagonism is not well established.
What to do
Monitor blood pressure, fluid status and urine output after starting fentanyl, particularly in patients with prostatic enlargement.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Fentanyl?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids can enhance antidiuretic hormone release and cause urinary retention, which may reduce diuretic effect. Fentanyl may also add to hypotension with antihypertensives. The effect is generally small and variable.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Fentanyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and urine output after starting fentanyl, particularly in patients with prostatic enlargement.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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