Drug interactions
Eprosartan-hydrochlorothiazide + Formoterol
Severity: Moderate
Eprosartan-hydrochlorothiazide and Formoterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Formoterol and hydrochlorothiazide can each lower serum potassium, so together they may cause clinically significant hypokalemia. This may predispose to arrhythmias, particularly at high formoterol doses or in patients with hypoxia or other risk factors.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Formoterol belongs to Respiratory.
Why it happens
Beta-2 agonism drives potassium into cells while thiazides increase renal potassium loss, giving additive hypokalemia.
What to do
Monitor serum potassium in patients on regular or high-dose formoterol, and replace potassium as needed. The potassium-sparing effect of the eprosartan component may partly offset the loss.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Formoterol?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Formoterol and hydrochlorothiazide can each lower serum potassium, so together they may cause clinically significant hypokalemia. This may predispose to arrhythmias, particularly at high formoterol doses or in patients with hypoxia or other risk factors.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Formoterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients on regular or high-dose formoterol, and replace potassium as needed. The potassium-sparing effect of the eprosartan component may partly offset the loss.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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