Drug interactions
Eprosartan-hydrochlorothiazide + Glibenclamide
Severity: Minor
Eprosartan-hydrochlorothiazide and Glibenclamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may raise blood glucose and reduce the effectiveness of glyburide. The effect is usually modest but can be relevant when glycemic control is borderline.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Glibenclamide belongs to Endocrine.
Why it happens
Thiazide-induced hypokalemia and reduced insulin secretion and sensitivity oppose the sulfonylurea effect.
What to do
Monitor blood glucose and HbA1c after starting the combination. Adjust the glyburide dose as needed and monitor potassium.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Glibenclamide?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may raise blood glucose and reduce the effectiveness of glyburide. The effect is usually modest but can be relevant when glycemic control is borderline.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Glibenclamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting the combination. Adjust the glyburide dose as needed and monitor potassium.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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