Drug interactions
Eprosartan-hydrochlorothiazide + Heparin
Severity: Moderate
Eprosartan-hydrochlorothiazide and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin can suppress aldosterone secretion, and combined with an angiotensin receptor blocker this may produce hyperkalemia. The risk is higher in patients with renal impairment, diabetes or prolonged heparin therapy. The thiazide component partially counteracts the effect.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Heparin belongs to Cardiovascular.
Why it happens
Heparin inhibits adrenal aldosterone synthesis and ARBs reduce aldosterone action, additively decreasing renal potassium excretion.
What to do
Check serum potassium at baseline and periodically during heparin treatment lasting more than a few days, especially in patients with diabetes or kidney disease. Treat hyperkalemia if it emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Heparin?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin can suppress aldosterone secretion, and combined with an angiotensin receptor blocker this may produce hyperkalemia. The risk is higher in patients with renal impairment, diabetes or prolonged heparin therapy. The thiazide component partially counteracts the effect.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium at baseline and periodically during heparin treatment lasting more than a few days, especially in patients with diabetes or kidney disease. Treat hyperkalemia if it emerges.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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